Organocatalytic, regioselective allylic- and 1,6-substitution of quinone monoketals with diaryl H-phosphine oxides

Add time:08/03/2019    Source:sciencedirect.com

An efficient selective synthesis of C- and O-phosphoryl-substituted phenols from easily available diaryl H-phosphine oxides with quinone monoketals (QMAs) has been developed. With the assistance of opponent characteristic additives (e.g., H2O and Et3N), diaryl H-phosphine oxides could selectively proceed the allylic- and 1,6-substitution to conjugate with the C-/O- positions of QMAs. The reported protocol is green and practical, and represents an efficient method to functionalize C-/O-phosphoryl-substituted phenols with moderate to good yields.

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