Differentiation of factor C-LHIH and the synthetic contraceptive polypeptide, H-Thr-Pro-Arg-Lys-OH

Add time:08/03/2019    Source:sciencedirect.com

SummaryThe contraceptive polypeptide designated by Kent and shown by him to be H-Thr-Pro-Arg-Lys-OH has been synthesized by a solid-phase procedure, and the tetrapeptide was purified and characterized. Factor C-LHIH, partially purified from porcine hypothalami, which inhibits the luteinizing hormone from basal release and from the synthetic luteinizing hormone releasing hormone (LHRH), and the synthetic H-Thr-Pro-Agr-Lys-OH are different by cation exchange and by other high pressure liquid chromatographic techniques. At high dosage, H-Thr-Pro-Arg-Lys-OH released FSH and to a lesser extent LH, but the tetrapeptide showed no antagonist activity against synthetic LHRH, even at very high levels.

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