New facile synthesis of furan-2(3H)-ones and 2,3,5-trisubstituted furans via intramolecular Wittig reaction of acid anhydride

Add time:08/04/2019    Source:sciencedirect.com

A new facile preparation of furan-2(3H)-ones and 2,3,5-trisubstituted furans by a sequential O-acylation/Wittig(/O-acylation) reaction has been developed. The easily accessible 2-(triphenylphosphoranylidene)-succinic acid 1-ester 3 reacted with acid chloride produced furan-2(3H)-ones 4 in good yields in the presence of DMAP via sequential O-acylation and intramolecular Wittig reaction of acid anhydride. Subsequently, the 2,3,5-trisubstituted furans 5 were prepared from furan-2(3H)-ones 4 and diverse aryl chlorides in presence of triethylamine through further O-acylation.

We also recommend Trading Suppliers and Manufacturers of 4-(3-OXO-PROPYL)-BENZOIC ACID METHYL ESTER (cas 113100-81-5). Pls Click Website Link as below: cas 113100-81-5 suppliers

Prev:Synthesis of Chromeno[3,4-c]pyridines by Rhodium(III)-Catalyzed Annulation of Coumarinyl Ketoxime Esters and Alkynes
Next:Atom transfer radical addition (ATRA) catalyzed by copper complexes with N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) ligand)