The MMP inhibitor (R)-2-(N-benzyl-4-(2-[18F]fluoroethoxy)phenylsulphonamido)-N-hydroxy-3-methylbutanamide: Improved precursor synthesis and fully automated radiosynthesis

Add time:08/03/2019    Source:sciencedirect.com

SummaryThe CGS 25966 derivative (R)-2-(N-Benzyl-4-(2-[18F]fluoroethoxy)phenyl-sulphonamido)-N-hydroxy-3-methylbutanamide [18F]9 represents a very potent radiolabelled matrix metalloproteinase inhibitor. For first human PET studies it is mandatory to have a fully automated radiosynthesis and a straightforward precursor synthesis available. The realisation of both requirements is reported herein. In particular, the corresponding precursor 8 was obtained in a reliable 7 step synthesis with an overall chemical yield of 2.3%. Furthermore, the target compound [18F]9 was prepared with a radiochemical yield of 14.8±3.9% (not corrected for decay).

We also recommend Trading Suppliers and Manufacturers of 2-[benzyl(1-methyl-2-phenoxyethyl)amino]ethanol (cas 101-45-1). Pls Click Website Link as below: cas 101-45-1 suppliers

Prev:Insight into photochemical oxidation of FENURON (cas 101-42-8) in water using iron oxide and oxalate: The roles of the dissolved oxygen
Next:Role of d-amphetamine and d-methamphetamine as active metabolites of benzphetamine: Evidence from drug discrimination and pharmacokinetic studies in male rhesus monkeys)