The metabolism of the nonionic surfactant 14C-labeled α[p-1,1,3,3-tetramethylbutyl)phenyl]-ω-hydroxyhexa(oxyethylene) in the goat

Add time:08/05/2019    Source:sciencedirect.com

A goat given a single dose of 14C-labeled α-[p-(1,1,3,3-tetramethylbutyl)phenyl]-ω-hydroxyhexa(oxyethylene) ([14C]TOP-6EOH) eliminated 18% of the 14C in the urine and 77% in the feces within 96 hr after dosing. Another goat (surgically modified for total bile collection) given a single dose of [14C]TOP-6EOH eliminated 81% of the 14C in the bile, 17% in the urine, and only 6% in the feces. When 14C-bile from the animal in the second study was perfused into the small intestine of a third goat, 72% of the 14C was eliminated in the feces, 20% in the bile, and 6% in the urine within 96 hr. Eighteen different types of metabolites accounting for most of the 14C in the bile and urine were isolated, derivatized, and then characterized by mass spectral analysis. The [14C]TOP-6EOH was metabolized by: (i) oxidation of the alkyl group to give alcohols and acids, (ii) oxidation of the terminal ethylene oxide moiety to an acid, (iii) cleavage of the polyoxyethylene side chain, (iv) combinations of i–iii, and (v) conjugation of the products of i–iv.

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