25-azacycloartanol (cas 73116-19-5), a potent inhibitor of S-adenosyl-L-methionine-sterol-C-24 and C-28 methyltransferases in higher plant cells

Add time:07/12/2019    Source:sciencedirect.com

25-azacycloartanol (1) is a potent inhibitor of S-adenosyl-L-methionine-cycloartenol-C-24-methyltransferase and of S-adenosyl-L-methionine-24-methylene lophenol-C-28-methyltransferase, two microsomal enzymes of maize (Zea mays) embryos. Addition of 1 to a suspension of bramble (Rubus fruticosus) cells grown in vitro resulted in a strong decrease of the 24-ethylsterol content and in a dramatic increase of sterols lacking an alkyl group at C-24.

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