Diastereoselective reduction of α-acyl-N-[Bis(methylthio)methylene]alaninates and phenylalaninates: Synthesis of α,α-disubstituted β-hydroxy α-amino esters

Add time:08/09/2019    Source:sciencedirect.com

Chemoselective reduction of the carbonyl group in α-acyl-N-[Bis(methylthio)methylene]-alaninates 1a-c and phenylalaninates 1d,e allowed for the diastereoselective synthesis of both the syn and the anti isomers of the corresponding N-protected α,α-disubstituted β-hydroxy-α-amino esters 2. The stereochemistry of the process was tuned by switching between chelation-controlled and non-chelation-controlled conditions for the reduction. Compounds 2 can be transformed into the corresponding N-unprotected α-quaternized β-hydroxy-α-amino esters 4.

We also recommend Trading Suppliers and Manufacturers of N,N'-Bis(1-methylpropyl)-1,4-phenylenediamine (cas 101-96-2). Pls Click Website Link as below: cas 101-96-2 suppliers

Prev:Mass Spectral Fragmentation of (S, S)-N, N′-Bis [1-(hydroxymethyl) alkyl] anthracene/Naphthalene-1, 8-dicarboxamides under Electron Impact Ionization Conditions1
Next:Preparation and characterization of mixed ethyl PHENYLURETHANE (cas 101-99-5)/titania particles)