Synthesis and NMR characterization of seven new substituted pyridine N-oxides

Add time:08/03/2019    Source:sciencedirect.com

Seven 3-substituted (alkylamino, alkylnitramino and alkylnitrosoamino) derivatives of pyridine N-oxide have been prepared and their 1H, 13C and 15N NMR chemical shifts assigned based on PFG 1H, 13C HMQC and PFG 1H, X (X = 13C or 15N) HMBC experiments. In the sterically most crowded congener, 3-ethylnitramino-4-nitropyridine N-oxide, chemical non-equivalence or diastereotopicity of the N–CH2 protons was observed probably due to the chirality of the adjacent amino nitrogen caused by its restricted inversion. The coalescence temperature for the 1H NMR chemical shifts of these geminal protons has been determined and the corresponding ΔG∗ for the energy barrier of the dynamic process has been estimated.

We also recommend Trading Suppliers and Manufacturers of 3-AMINO-4-NITROPYRIDINE N-OXIDE (cas 19349-78-1). Pls Click Website Link as below: cas 19349-78-1 suppliers

Prev:Design, synthesis and structure–activity relationship of phthalimides endowed with dual antiproliferative and immunomodulatory activities
Next:Behavior of γ-Al2O3-bonded-3-chloropropyltrimethoxysilane nanosorbent toward potential binding and removal of 4-nitroaniline and 2-amino-3-nitro-pyridine from water)