The metabolic activation of 7-methylbenz(a)anthracene in mouse skin

Add time:08/04/2019    Source:sciencedirect.com

The metabolism of 7-methylbenz(a)anthracene by rat-liver preparations and by mouse skin has been studied using a combination of thin-layer and high pressure liquid chromatography and all five possible trans-dihydrodiols have been detected as metabolites but in different proportions. The roles of these dihydrodiols and of the related vicinal diol-epoxides in the metabolic activation of 7-methylbenz(a)anthracene in mouse skin has been studied using Sephadex LH-20 column chromatography. The results show that the hydrocarbon-nucleic acid products formed in mouse skin in vivo most probably arise from 3,4-dihydro-3,4-dihydroxy-7-methylbenz(a)anthracene 1,2-oxide which, on the basis of this and other evidence, appears to be the reactive intermediate involved in the metabolic activation of 7-methylbenz(a)anthracene in this tissue.

We also recommend Trading Suppliers and Manufacturers of 7-METHYL-12-ETHYLBENZ(A)ANTHRACENE (cas 16354-55-5). Pls Click Website Link as below: cas 16354-55-5 suppliers

Prev:Comparative metabolism of 7-methyl- and 7-ethylbenz[a]anthracene by rat-liver preparations
Next:Influences of 7-alkyl substitution on the reversible binding of the proximate carcinogen trans-3,4-dihydroxy-3,4-dihydrobenz[a]anthracene to DNA)