Synthesis of cis-2-alkoxycyclopropylamines via intramolecular cyclization of 2-azaallylic anions derived from alkoxybrominated N-(arylidene)-2-methyl-2-propenylamines
-
Add time:07/13/2019 Source:sciencedirect.com
N-(Arylidene)-2-alkoxy-3-bromo-2-methylpropylamines, obtained in a straightforward way via regiospecific alkoxybromination of the corresponding N-(2-methyl-2-propenyl)imines, represent promising densely functionalized synthetic building blocks. The substituted N-(3-bromopropyl)imines were deprotonated to the corresponding 2-azaallylic anions, which underwent a highly diastereoselective intramolecular ring closure to new cis-N-(arylidene)-2-alkoxy-2-methylcyclopropylamines (cis:trans up to 99:1) in good to excellent yields (62–95%). These cis-cyclopropylamines proved to be excellent precursors of new conformationally constrained β-amino ethers.
We also recommend Trading Suppliers and Manufacturers of N-Methyl-N'-(2-propenyl)-1,2-hydrazinedicarbothioamide (cas 5638-74-4). Pls Click Website Link as below: cas 5638-74-4 suppliers
Prev:Theoretical DFT, vibrational and structural characterization of 1-propenyl-2-methylbenzimidazole and its isomers
Next:The α-asarone/clofibrate hybrid compound, 2-methoxy-4-(2-propenyl)phenoxyacetic acid (MPPA), is endowed with neuroprotective and anticonvulsant potentialities) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Synthesis and antibacterial activities of 6-O-methylerythromycin A 9-O-(3-aryl-2-propenyl) oxime ketolide, 2,3-enol ether, and alkylide analogues07/19/2019
- Design and synthesis of novel leucomycin analogues modified at the C-3 position. Part II: 3-O-(3-Aryl-2-propenyl)leucomycin analogues07/18/2019
- The synthesis and enzymic hydrolysis of (E)-2-[2,3-2H2]propenyl glucosinolate: Confirmation of the rearrangement of the thiohydroximate moiety07/17/2019
- Resolution of (R,S)-4-Hydroxy-3-methyl-2-(2-propenyl)-2-cyclopenten-1-one Catalyzed by Lipase in Ionic Liquid07/16/2019
- Synthesis, structural and conformational studies of Z- and E-isomers of fluorinated C-6 isobutenyl N-methyl thymine derivatives07/15/2019
- The α-asarone/clofibrate hybrid compound, 2-methoxy-4-(2-propenyl)phenoxyacetic acid (MPPA), is endowed with neuroprotective and anticonvulsant potentialities07/14/2019
- Theoretical DFT, vibrational and structural characterization of 1-propenyl-2-methylbenzimidazole and its isomers07/12/2019
- PEPPSI-type 2-methyl-2-propenyl-functionalized N-heterocyclic carbene-palladium complexes: Synthesis, structural characterization and catalytic activity on Suzuki–Miyaura reaction07/11/2019
