Partial separation of beef adrenal Δ5-3-ketosteroid isomerases: Androst-5-ene-3,17-dione isomerase and pregn-5-ene-3,20-dione (cas 1236-09-5) isomerase

Add time:08/04/2019    Source:sciencedirect.com

Two distinct Δ5-3-ketosteroid isomerases, one acting on the androst-5-ene-3,17-dione and the other on pregn-5-ene-3,20-dione (cas 1236-09-5), were demonstrated in beef adrenal cortex homogenates and were partly separated by ammonium sulfate fractionation from a solubilized preparation of the glands. In one enzyme fraction, androst-5-ene-3,17-dione isomerase was almost free of pregn-5-ene-3,20-dione isomerase activity. In a second fraction, pregn-5-ene-3,20-dione isomerase was twice as active as androst-5-ene-3,17-dione isomerase, whereas in the solubilized preparation androst-5-ene-3,17-dione isomerase was 5–8 times as active as pregn-5-ene-3,20-dione isomerase.

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