Spectroscopic studies on the anticancer antibiotic Altromycin H and the interaction with copper(II) ions

Add time:08/04/2019    Source:sciencedirect.com

The antitumor antibiotic Altromycin H was studied using electronic absorption (UV–Vis.) and circular dichroism (CD) spectroscopy. The dissociation constants of the phenolic groups on C(5) and C(11) were estimated as pK1 = 6.7 and pK2 = 11.8 at 25 °C, respectively, and a complete assignment of the CD and UV–Vis. bands is proposed. The interaction of Cu(II) ions with the Altromycin H has been also investigated by UV–Vis., CD and electron paramagnetic resonance (EPR) spectroscopy. A pH depended stepwise complex formation was observed. At pH < 4 no copper–Altromycin H interactions were detected. At the 4 < pH < 8 the Cu(II) ions coordinate to Altromycin H via the C(4)O and C(5)OH groups atoms of the chromophore ring and the [Cu(AltroH)2] complex (formation constant, Kf, 4.00 ± 0.9 × 1011 M−2 at 25 °C) is the predominant species. In alkaline solution the hydroxo-bridged complex, [Cu(OH)(AltroH)]2, is proposed to be as the unique present species.

We also recommend Trading Suppliers and Manufacturers of altromycin E (cas 134887-77-7). Pls Click Website Link as below: cas 134887-77-7 suppliers

Prev:Synthesis of some metallophthalocyanines bearing 9-phenyl-9H-fluoren-9-yl) oxy functional groups and investigation of their photophysical properties
Next:Studies on the interaction of altromycin B and its platinum(II) and palladium(II) metal complexes with calf thymus DNA and nucleotides)