Synthesis of 5-hydroxy-4-methoxytricyclo[7.3.1.02,7]trideca-2,4,6-trien- 8-one – precursor of putative bioisosteric colchicine analogues

Add time:08/06/2019    Source:sciencedirect.com

Hydroxy-4-methoxytricyclo[7.3.1.02,7]trideca-2,4,6-trien-8-one was synthesized from 1-benzyloxy-4-bromo-2-methoxybenzene in six steps comprising Corey–Chaykovsky epoxidation and Friedel–Crafts intramolecular cyclization. The crystal structure of the benzyl-protected derivative of the target compound was determined by X-ray analysis.

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