A simple method, using 2-hydroxypropyl-β-cyclodextrin, of administering α-chloralose at room temperature

Add time:08/04/2019    Source:sciencedirect.com

Effective long term stable anaesthesia is a goal of many drug regimens employed in neuroscience in which procedures carried out are not practical in awake animals. A particular problem is the study of nociceptive mechanisms where good anaesthesia is essential. Similarly studies of cardiovascular or cerebrovascular mechanisms require that normal physiological reflexes be preserved as much as is practical. For non-recovery anaesthesia α-chloralose is a good choice since it provides good anaesthesia without excess depression of physiological reflexes. However, α-chloralose is sparingly soluble so that its use is not straightforward. We describe the characterisation of a simple procedure to solubilise α-chloralose in a solution of 2-hydroxypropyl-β-cyclodextrin. The resulting solution is stable at room temperature and gives a high concentration of α-chloralose making it easier to administer regularly during longer time course experiments.

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