Unusual metabolism of sulfur-containing amino acids in rats treated with dl

Add time:08/05/2019    Source:sciencedirect.com

S-(2-Hydroxy-2-carboxyethyl)homocysteine, S-(3-hydroxy-3-carboxy-n-propyl)-cysteine, N-acylated S-(β-carboxyethyl)cysteine, and N-acylated S-(3-hydroxy-3-carboxy-n-propyl) cysteine were excreted in the urine after dl-propargylglycine treatment. Cystathionine was also accumulated in several tissues of dl-propargylglycine-treated rats. N-Monoacetylcystathione was found in the liver of rats and was also detected in the kidney and serum. Cystathionine γ-lyase activity in liver decreased to about 4% of that of control rats 24 h after the dl-propargylglycine injection, and alanine aminotransferase activity decreased to about 35% of that of control rats. On the other hand, aspartate aminotransferase and cystathionine β-synthese activity did not show significant changes from those of control rats. The ability of normal tissues to synthesize cystathionine utilizing cystathionine β-synthase was 1.98 ± 0.40 μmol/ min/g in liver, 0.61 ± 0.13 in kidney, and 0.18 ± 0.015 in brain. The maximal contents of cystathionine in rat tissues and the administered amounts of dl-propargylglycine agreed well with the ability to synthesize cystathionine in each tissue.

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