A single point chiral inversion that selforganizes a randomcoil peptide. Apolar solvent conformation of Boc-(L\D)-Glu-Ala-Leu-LysNHMe

Add time:08/05/2019    Source:sciencedirect.com

The tetrapeptide Boc-L-Glu-Ala-Leu-LysNHMe (1) reveals a random coil conformation, based on its Glu(γ) and Lys(ɛ) methylene proton aniosotropic shift, GluNH chemical shift, NOEs in chloroform-DMSO (6:1), and its amide proton temperature coefficients in DMSO, while on similar considerations, the diastereomer Boc-D-Glu-Ala-Leu-LysNHMe (2) is characterized as a highly ordered 3/10 type distorted protohelix with a remarkably stable intramolecular salt bridge under these solvent conditions.

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