Optically active 6-acetyloxy-2H-pyran-3(6H)-one obtained by lipase catalyzed transesterification and esterification

Add time:08/04/2019    Source:sciencedirect.com

Kinetic resolution of 6-acetyloxy-2H-pyran-3(6H)-one (1) is achieved by immobilized lipase PS on Hyflo Super Cell in organic solvents. Transesterification in hexane/n-butanol yields enantiomerically pure R-(−)-6-acetyloxy-2H-pyran-3(6H)-one, whereas esterification of 6-hydroxy-2H-pyran-3(6H)-one (2) with vinyl acetate by immobilized lipase PS gives the S-enantiomer with e.e.'s up to 76%.

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