Effect of copper substitution on the local chemical structure and dissolution property of copper-doped β-tricalcium phosphate

Add time:08/05/2019    Source:sciencedirect.com

Substitution of inorganic ions into β-tricalcium phosphate (β-TCP) is a well-known approach for facilitating biological functions of bioceramics. However, the dissolution mechanism of those β-TCPs is still under intensive debates. In the present study, the effect of copper substitution into β-TCP crystal structure on the local chemical structure and dissolution property of the copper-doped β-TCP (CuTCP) was investigated to clarify the dissolution mechanism of β-TCP. A copper-dependent decrease in the dissolution rate of CuTCP with time was observed. The 1H → 31P nuclear magnetic resonance (NMR) spectra of 10 mol% copper-doped β-TCP after the dissolution test demonstrated an amorphous hydrated layer on the surface of β-TCP core particles, which contained hydroxyapatite and dicalcium phosphate dihydrate and anhydrate. As such, all the dissolution curves could be curve-fitted by a heterogeneous dissolution model composing of fast and slow dissolution components. Overall, dissolution mechanism could be proposed as follows: the CuTCP particles initially dissolved by hydrolysis based on the fast dissolution component. Subsequently, the amorphous hydrated layers were formed on their surface, and caused the diffusion-controlled dissolution. As the result, the slow dissolution component would be dominant, and led to the decreased dissolution rate.

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