Synthesis of 8-aminoadenosine 5′-(aminoalkyl phosphates), analogues of aminoacyl adenylates

Add time:08/05/2019    Source:sciencedirect.com

A short and efficient route for the synthesis of aminoalkyl 8-aminoadenylates, potential aminoacyl-tRNA synthetase inhibitors, is presented. Aminoalkyl 8-aminoadenylates were synthesized using a 5′-H-phosphonate strategy involving minimal protecting group manipulations and a single final deprotection step.

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