Thermal degradation of sugar-modified uridine N-oxides: Olefination, oxazolidination and rearrangements
-
Add time:08/09/2019 Source:sciencedirect.com
The degradation pattern of the N-oxides of various tertiary aminouridines is established. The N-oxide of 3′-deoxy-3′-morpholino-arauridine generated double bonds in the carbohydrate moiety without much selectivity, whereas epimino uridine N-oxides generated only d4U. Oxazolidine derivatives were formed from the N-oxides of 3′-deoxy-3′-N-pyrrolidino/morpholino-2,2′-O-anhydrouridines and 3′-deoxy-3′-N-pyrrolidino/morpholino-2′-O-mesylarauridines. 2′-Deoxy-2′-N-pyrrolidino/morpholino-2′-O-mesylxylouridines produced rearranged products 3′-O-N-pyrrolidino/morpholino-2,2′-O-anhydrouridines.
We also recommend Trading Suppliers and Manufacturers of Uridine, 4',5'-didehydro-5'-deoxy- (cas 14365-63-0). Pls Click Website Link as below: cas 14365-63-0 suppliers
Prev:Effects of modifications in the pentose moiety and conformational changes on the binding of nucleoside ligands to uridine phosphorylase from Toxoplasma gondii
Next:Selective protection of toxicity of 2′,3′-dideoxypyrimidine nucleoside analogs by β-d) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Synthesis of new 2′, 3′-modified uridine derivatives from 2′,3′-ene-2′-phenylselenonyl uridine by Michael addition reactions08/11/2019
- Selective protection of toxicity of 2′,3′-dideoxypyrimidine nucleoside analogs by β-d08/10/2019
- Effects of modifications in the pentose moiety and conformational changes on the binding of nucleoside ligands to uridine phosphorylase from Toxoplasma gondii08/08/2019
- 5′-Epimeric 3′-deoxy-3′,4′-didehydronucleoside-5′-C-phosphonates: synthesis and structural assignment by NMR and X-ray analyses08/07/2019
- Synthesis and P2Y2 receptor agonist activities of uridine 5′-phosphonate analogues08/06/2019
- Synthesis of 3′-deoxyadenosine-3′-spirocyclopropane, 3′-deoxy-uridine-3′-spirocyclopropane, and 5′-deoxy-4′,5′-methanoadenosine08/05/2019
