Studies on the asymmetric, phosphine-promoted [3+2] annulations of allenic esters with 2-aryl-1,1-dicyanoalkenes

Add time:08/05/2019    Source:sciencedirect.com

The first enantioselective variant of the phosphine-promoted [3+2] cycloaddition reaction between allenoates and 2-aryl-1,1-dicyanoethylenes has been developed. The use of (S)-t-butyl-Binepine as the chiral organocatalyst allows the synthesis of functionalized cyclopentenes with both aryl and heteroaryl substituents on the stereogenic carbon, in high yields and ees of up to 95%.

We also recommend Trading Suppliers and Manufacturers of ETHYL 2 3-BUTADIENOATE 95 (cas 14369-81-4). Pls Click Website Link as below: cas 14369-81-4 suppliers

Prev:Determination of two mebeverine metabolites, mebeverine alcohol (cas 14367-47-6) and desmethylmebeverine alcohol (cas 14367-47-6), in human plasma by a dual stable isotope-based gas chromatographic-mass spectrometric method
Next:Asymmetric synthesis of novel highly sterically constrained (2S,3S)-3-methyl-3-trifluoromethyl- and (2S,3S,4R)-3-trifluoromethyl-4-methylpyroglutamic acids)