Enhanced efficacy of Baicalin (cas 100647-26-5)-loaded TPGS polymeric micelles against periodontitis

Add time:08/05/2019    Source:sciencedirect.com

As a chronic infectious disease, periodontitis is the main cause of teeth exfoliation due to its severe inflammatory reaction and periodontal tissue destruction. Recent reports have shown that baicalin could inhibit the NF-κB signaling pathway in inflammatory activity of periodontitis, but the efficacy of baicalin is limited due to its poor water solubility. In this work, we report the fabrication and application of baicalin encapsulated D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) polymeric micelles (PMs) through thin-film hydration method. The monodispersed micelles showed a spherical shape in aqueous solution and a prolonged drug-release kinetic. After baicalin was loaded into PMs, cytotoxicity and apoptosis induction were both decreased. The expression of genes (including TNF-α, IL-1β, RANKL and NF-κB) and the phosphorylation level of NF-κB p65 protein in lipopolysaccharide (LPS)-induced rat gingival fibroblasts were also reduced. Further investigation of drug efficacy in a rat periodontal disease model confirmed that the use of baicalin-PMs could reduce the destruction of alveolar bone and gingival fiber. Moreover, the therapeutic effect of baicalin-PMs was significantly better than that of free baicalin. These results suggest that the direct injection of micelles containing water-insoluble drugs may become a simple but effective method for treating periodontitis.

We also recommend Trading Suppliers and Manufacturers of Baicalin (cas 100647-26-5). Pls Click Website Link as below: cas 100647-26-5 suppliers

Prev:Behavior of quizalofop-p and its commercial products in water by liquid chromatography coupled to high resolution mass spectrometry
Next:Baicalin (cas 100647-26-5) regulates depression behavior in mice exposed to chronic mild stress via the Rac/LIMK/cofilin pathway)