Modification of calcium phosphate cement with poly (γ-glutamic acid) and its strontium salt for kyphoplasty application

Add time:08/09/2019    Source:sciencedirect.com

To meet the requirements of minimally invasive surgical treatments for osteoporotic vertebral compression fracture, various strategies have been proposed to enhance the properties of calcium phosphate cement (CPC). Here, a new strategy was developed by incorporating poly (γ-glutamic acid) (γ-PGA) and its strontium salt into the formulation of alpha tricalcium phosphate (α-TCP)-based CPC. Effects of γ-PGA on the injectability, cohesion, setting times, mechanical compressive strengths and cytocompatibility were systematically studied. Results showed that the injectability, cohesion and setting times were considerably improved by introducing γ-PGA into the CPC. Moreover, after setting for 7 days, the compressive strengths increased from 14.6 ± 1.4 MPa for pure CPC to 35.3 ± 1.7 MPa for CPC with 8.9 wt% γ-PGA and further to 61.2 ± 5.4 MPa for CPC with 8.9 wt% γ-PGA combined with its strontium salt. In vitro osteoblast proliferation tests showed that the group of CPC modified by γ-PGA and its strontium salt had better cytocompatibility than the pure CPC group. All results suggest that optimal properties were obtained for the cement with 8.9 wt% γ-PGA added to its solid phases and using strontium salt as the reactive liquid phase, making it as a promising candidate for application in kyphoplasty.

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