Stereoselective bioreduction for the resolution of racemic mixtures of bicyclo[3.3.1]nonane-2,6-dione using vegetables

Add time:08/06/2019    Source:sciencedirect.com

Screening of various vegetables as biocatalysts for the stereoselective bioreduction and resolution of racemic BICYCLO[3.3.1]NONANE-2,6-DIONE (cas 16473-11-3) was performed. Vegetables of the family Apiaceae, i.e. the roots of parsnip (Pastinaca sativa), celery (Apium graveolens), parsley (Petroselinum crispum) and carrot (Daucus carota) were found to be the best. The methodology described here allows the efficient enantioseparation of (+)-enantiomer of bicyclo[3.3.1]nonane-2,6-dione. The reaction time, temperature and the amount of celery roots were optimized and (+)-enantiomer was obtained with the optical purity of 90–98% and the yield of more than 90%.

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