A concise synthesis of methyl 2,6-dideoxy-2-fluoro-β-l

Add time:08/08/2019    Source:sciencedirect.com

The 4,6-benzylidene acetal of methyl 2-deoxy-2-fluoro-α,β-d-glucopyranoside underwent inversion at C-3 via an oxidation–reduction sequence, and treatment of the derived 3-acetate with N-bromosuccinimide in carbon tetrachloride gave methyl 3-O-acetyl-4-O-benzoyl-6-bromo-2,6-dideoxy-2-fluoro-α-d-allopyranoside (6). Dehydrobromination of 6 and reduction of the resultant 5,6-ene gave the 5-epimer of 6, which after removal of the ester substituents, afforded the title compound in good overall yield.

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