Evaluation of pancreatic VMAT2 binding with active and inactive enantiomers of 18F-FP-DTBZ in baboons

Add time:08/10/2019    Source:sciencedirect.com

Introduction18F-Fluoropropyl-(+)-dihydrotetrabenazine (18F-FP-(+)-DTBZ) is a vesicular monoamine transporter type 2 (VMAT2) radiotracer for positron emission tomography (PET) imaging to quantify human β-cell mass. Renal cortex and spleen have been suggested as reference regions, however, little is known about 18F-FP-(+)-DTBZ binding in these regions including the fraction of radiometabolite. We compared the kinetics of 18F-FP-(+)-DTBZ and its inactive enantiomer 18F-FP-(−)-DTBZ in baboons, estimated the non-displaceable binding (VND) of the tracers, and used ex vivo studies to measure radiometabolite fractions.

We also recommend Trading Suppliers and Manufacturers of FP 33 (cas 106909-37-9). Pls Click Website Link as below: cas 106909-37-9 suppliers

Prev:FP+DIC for low-cost 3D full-field experimental modal analysis in industrial components
Next:Controlling light absorption and transmission in graphene-embedded structure with Fano resonance and FP resonance)