Condensation of diethyl fluoromethylphosphonate with esters: An alternative synthetic route to diethyl α-fluoro-β-ketophosphonates

Add time:07/11/2019    Source:sciencedirect.com

New general and operationally simple method for preparation of racemic diethyl α-fluoro-β-ketophosphonates has been developed. Addition of LDA to solution of diethyl fluoromethylphosphonate and aromatic, heteroaromatic and aliphatic esters in THF at −78 °C afforded the corresponding diethyl α-fluoro-β-ketophosphonates in good to high yields.

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