TYRPHOSTIN A9 (cas 10537-47-0) improves blastocyst development in porcine embryos through induction of dynamin-related protein 1-dependent mitochondrial fission

Add time:08/07/2019    Source:sciencedirect.com

Mitochondrial dynamics are associated with the development of porcine embryos. However, little is known about the effects of mitochondrial dynamics-related genes (Drp1 and pDrp1-Ser616) on early porcine embryo development. Here, we investigated the effect of Drp1-dependent mitochondrial fission signaling on the development of porcine embryos using the mitochondrial fission inducer, TYRPHOSTIN A9 (cas 10537-47-0) (TA9). We determined that TA9 (1 μM) treated embryos were increased the mitochondrial functions, blastocyst development rate and quality, as well as decreased mitochondria-specific superoxide and mitochondrial apoptosis. Thus, TA9-induced appropriate mitochondrial fission improved the developmental competence via maintenance of a balance in mitochondrial dynamics in porcine embryo.

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