A convenient and new approach to the synthesis of ω-heterocyclic amino acids from carboxy lactams through ring-chain-transformation. Part 2: Synthesis of (2R)-/(2S)-2-aminomethyl-3-(1-aryl-/1,5-diaryl-1H-pyrazol-3-yl)-propionic acid

Add time:08/06/2019    Source:sciencedirect.com

Making use of amide activation, a convenient and short path synthesis of optically pure ω-heterocyclic-β-amino acids has been achieved from (1R,3R)- and (1R,3S)-5-oxo-1-(1-phenyl-ethyl)-pyrrolidine-3-carboxylic acid methyl ester. The key step of the synthesis involves a regiospecific ring-chain-transformation of the enaminones when subjected to 1,2-binucleophilic attacks. The method is illustrated by the synthesis of (2R)-/(2S)-2-aminomethyl-3-(1-aryl-/1,5-diaryl-1H-pyrazol-3-yl)-propionic acid.

We also recommend Trading Suppliers and Manufacturers of 3-(2-Fluorophenyl)propionic acid (cas 1643-26-1). Pls Click Website Link as below: cas 1643-26-1 suppliers

Prev:The influence of heptane-1,2,3-triol on the size and shape of LDAO (cas 1643-20-5) micelles Implications for the crystallisation of membrane proteins
Next:Solubilities and thermodynamics of TPP in propionic acid + water and TPPMnCl in N,N-dimethylformamide + water solvent mixtures at (303.2–343.2) K)