Carbonylative and direct Suzuki–Miyaura cross-coupling reactions with 1-iodo-cyclohexene

Add time:08/06/2019    Source:sciencedirect.com

The Suzuki–Miyaura reaction of 1-iodo-cyclohexene and phenylboronic acid (or 3-trifluoromethoxy-phenylboronic acid) was investigated concerning the detailed analyses of the catalytic mixtures. The reaction was carried out both under argon (‘direct’ Suzuki–Miyaura coupling) and carbon monoxide (‘carbonylative’ Suzuki–Miyaura reaction). Palladium(II) acetate based in situ formed palladium(0) catalysts were used as catalytic system. The detailed analysis revealed the importance of the formation of the Heck-products and the homo-coupling of the substrate. The corresponding alkenyl-aryl-ketone was obtained by carbon monoxide insertion into palladium(II)-aryl bond.

We also recommend Trading Suppliers and Manufacturers of 1-BroMo-2-(trifluoroMethoxy)ethane (cas 1645-93-8). Pls Click Website Link as below: cas 1645-93-8 suppliers

Prev:Addition of carbonyl fluoride to aliphatic nitriles: Formation of α,α-difluoroalkyl isocyanates
Next:Synthesis, characterization and spectroscopic investigation of N-(2-Acetylbenzofuran (cas 1646-26-0)-3-yl)acrylamide monomer: Molecular structure, HOMO–LUMO study, TD-DFT and MEP analysis)