Zeolite-catalyzed acylation of heterocyclic compounds — VI. One-step synthesis of 3-(benzofuran-2-carbonyl)pentane-2,4-dione from 2-Acetylbenzofuran (cas 1646-26-0) over HY-zeolite
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Add time:08/07/2019 Source:sciencedirect.com
The reaction between 2-Acetylbenzofuran (cas 1646-26-0) and acetic anhydride at 60°C in the presence of HY-zeolite (SiAl = 16) led to a single final product: 3-(benzofuran-2-carbonyl)pentane-2,4-dione resulting from two consecutive acylation steps on the side chain. It was obtained in a 90% purity at around 50% conversion of 2-acetylbenzofuran. Other minor products and intermediates were also identified. A mechanism is proposed to account for the formation of the various products.
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