Vasoconstrictor effects of midodrine, ST 1059, noradrenaline, etilefrine and norfenefrine on isolated dog femoral arteries and veins

Add time:08/06/2019    Source:sciencedirect.com

ST 1059, the pharmacologically active metabolite of midodrine, is a potent arterial and venous vasoconstrictor on isolated dog femoral vascular strips; ST 1059 is less potent than noradrenaline or norfenefrine, but more potent than etilefrine. Midodrine itself does not elicit any constrictory effects in this continuously perfused preparation. The α-adrenergic blocking agent phentolamine shifts the concentration-response curve of ST 1059 to the right. The maximum effect of very high ST 1059 concentrations is somewhat depressed.

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