Manganese(II) complexes of tolfenamic acid or naproxen in polymeric structures or encapsulated in [15-MC-5] manganese(III) metallacrowns: Structure and biological activity

Add time:08/07/2019    Source:sciencedirect.com

The interaction of MnCl2 with the non-steroidal anti-inflammatory drugs tolfenamic acid (Htolf) or naproxen (Hnap) in the presence of salicylhydroxamic acid (H3shi) led- to the formation of the hexanuclear mixed-valence MnIIMnIII5 clusters [Μn6(tolf)2(shi)5(py)6], 1 and [Μn6(nap)(Hsal)(shi)5(py)6], 2 (where H2sal = salicylic acid) which were characterized as 15-metallacrown-5 complexes accommodating the Mn(II) ion and the monoanionic carboxylato ligands tolf−1, nap−1 and Hsal−1. The interaction of Mn(II) with deprotonated naproxen led to the formation of the polymeric Mn(II) complex [Μn(nap)2(CH3OH)]n, 3. All three complexes were characterized by physicochemical and spectroscopic techniques and by single-crystal X-ray crystallography. The in vitro cytotoxic effects of the complexes were evaluated against three cancer cell lines (HeLa, MCF-7 and A549 cells) as well as their combinatory activity with the well-known chemotherapeutic drugs irinotecan, cisplatin, paclitaxel and 5-fluorouracil. The interaction of complexes 1–3 with calf-thymus (CT) DNA and bovine serum albumin (BSA) was investigated in vitro by diverse techniques. In addition, the cytotoxic activity of the previously reported polymeric complex [Μn(tolf)2(DMF)2]n, 4 was also investigated and its behavior towards CT DNA and BSA was compared to that of complexes 1–3.

We also recommend Trading Suppliers and Manufacturers of ANTHRANILIC ACID MANGANESE(II) SALT (cas 15336-23-9). Pls Click Website Link as below: cas 15336-23-9 suppliers

Prev:Electrocatalytic oxidation of As(III) to As(V) using noble metal–polymer nanocomposites
Next:Comparative genotoxicity of 3-hydroxyanthranilic acid and anthranilic acid in the presence of a metal cofactor Cu (II) in vitro)