Quantification of GABAA receptors in the rat brain with [123I]iomazenil (cas 127396-36-5) SPECT from factor analysis-denoised images

Add time:08/09/2019    Source:sciencedirect.com

PurposeIn vivo imaging of GABAA receptors is essential for the comprehension of psychiatric disorders in which the GABAergic system is implicated. Small animal SPECT provides a modality for in vivo imaging of the GABAergic system in rodents using [123I]Iomazenil, an antagonist of the GABAA receptor. The goal of this work is to describe and evaluate different quantitative reference tissue methods that enable reliable binding potential (BP) estimations in the rat brain to be obtained.

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