The synthesis of conformationally constrained analogues of the ACE inhibitor Idrapril (cas 127420-24-0)

Add time:08/08/2019    Source:sciencedirect.com

A conformationally constrained analogue 3 of the ACE inhibitor Idrapril has been prepared by a five-step synthesis. The key step in the synthesis is the desymmetrization of endo-norborn-5-ene-2,3-dicarboxylic anhydride 4 by reaction with t-butyl (S)-prolinate.

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