Synthesis of both D- and L-Fmoc-Abu[PO(OCH2CHCH2)2]-OH for solid phase phosphonopeptide synthesis

Add time:07/12/2019    Source:sciencedirect.com

The Schöllkopf bislactim ether asymmetric amino acid synthesis was coupled with a subsequent enzyme mediated ester hydrolysis to generate a practical synthesis of both D and L enantiomers of Fmoc-Abu[PO(OCH2CHCH2)2]-OH (6). With this building block phosphonopeptide isosteres of serine phosphopeptides are accessible by Fmoc-solid phase peptide synthesis.

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