3-[(3-(Trimethoxysilyl)propyl)thio]propane-1-oxy-sulfonic acid: An efficient recyclable heterogeneous catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones

Add time:08/10/2019    Source:sciencedirect.com

An efficient method for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and thiones through one-pot three-component reaction of ethyl acetoacetate, aryl aldehyde and urea or thiourea in ethanol using 3-[(3-(trimethoxysilyl)propyl)thio]propane-1-oxy-sulfonic acid as catalyst is described. The use of 3-[(3-(trimethoxysilyl)propyl)thio]propane-1-oxy-sulfonic acid as a catalyst offers several advantages such as high yields, short reaction times, mild reaction condition and a recyclable catalyst with a very easy work up.

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