Effects of atropine and azaprophen (cas 107010-27-5) on matching and detection in rhesus monkeys

Add time:08/07/2019    Source:sciencedirect.com

The effects of the anticholinergic atropine and azaprophen (cas 107010-27-5), a novel, conformationally restricted analog of atropine, were examined in rhesus monkeys using delayed match-to-sample and detection tasks. Both compounds (0.01–0.32 mg/kg) produced dose-dependent decreases in the rate of responding under both tasks. Drug effects on the match-to-sample task correlated with drug effects on the detection task. Both compounds produced decreases in the percentage of correct responses on the match-to-sample task when choice trials occured 4 or 16 sec, but not 0.01 sec, following sample presentation. Doses of atropine and azaprophen decreasing accuracy on the match-to-sample task also decreased the number of responses on the task. In general, atropine was slightly more potent than azaprophen on both tasks. These results further characterize azaprophen's anticholinergic effects.

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