Oxone®-mediated direct arylselenylation of imidazo[2,1-b]thiazoles, imidazo[1,2-a]pyridines and 1H-pyrazoles

Add time:08/07/2019    Source:sciencedirect.com

Oxone mediated reaction of imidazo[2,1-b]thiazole, imidazo[1,2-a]pyridine and 1H-pyrazole derivatives with diaryl diselenides is presented here. The methodology represents an efficient and simple protocol for carrying out the selective synthesis of 5-arylselanyl-imidazo[2,1-b]thiazoles, 3-arylselanyl-imidazo[1,2-a]pyridines and 4-arylselanyl-1H-pyrazoles in high yields using a stable, nontoxic and cheap oxidant. The reactions were conducted at 60 °C in air using acetonitrile as solvent. Alternatively, the use of ultrasound irradiation is presented as a tool for fast and efficient energy transfer that significantly reduced the reaction time.

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