Stereoselectivity in bis(α-amino acid)copper(II) complexes—IV[10]

Add time:07/12/2019    Source:sciencedirect.com

Ligand-exchange chromatography data, polarimetric titration and electronic spectra show that in the mixture of (CuL2), (CuD2) and CuLD) complexes formed by Cu(II) ions with racemic N-benzyl-dl-valine in aqueous or methanolic solutions the equally-paired structures (CuD2) and (CuL2) are more stable compared to the meso-structure (CuLD). The latter is probably destabilized by some kind of interligand interactions, which follows from the study of CD-spectra of Cu(N-Bz-L-Val)2 and Cu(N-Bz-L-Val)(Gly) complexes. X-ray study of the molecular structure of the complex Cu(N-Bz-L-Val)2 · 3H2O combined with the known structures of two forms of the complex Cu(N-Bz-L-Val)(N-Bz-D-Val) · 2H2O makes it possible to explain enantioselectivity in this system by the steric hindrance of coordination of the solvent molecules in the axial positions of the meso-complex.

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