Benzamide derivatives and their constrained analogs as histamine H3 receptor antagonists

Add time:07/13/2019    Source:sciencedirect.com

A series of 4-(1-substituted piperidin-4-yloxy) benzamides and 6-(1-substituted piperidin-4-yloxy)-3,4-dihydro-2H-isoquinolin-1-one derivatives have been synthesized and tested for their binding affinity towards H3 receptor. Most of these synthesized compounds have displayed potent binding affinity for H3 receptor when tested in in vitro binding assay. Preliminary SAR studies, functional activity, pharmacokinetic profile and efficacy profile constitute the subject matter of this communication.

We also recommend Trading Suppliers and Manufacturers of 2-Chloro-N-(3-Methoxyphenyl)benzaMide, 97% (cas 65382-87-8). Pls Click Website Link as below: cas 65382-87-8 suppliers

Prev:Ortho lithiation-in situ borylation of substituted morpholine benzamides
Next:Fabrication of PCL/PVP Electrospun Fibers loaded with Trans-anethole for Bone Regeneration in vitro)