UV-induced DNA methyltransferase 1 promotes hypermethylation of tissue inhibitor of metalloproteinase 2 in the human skin
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Add time:08/15/2019 Source:sciencedirect.com
BackgroundUltraviolet (UV) radiation has been reported to influence epigenetic regulation by affecting the expression of genome regulators such as DNA methyltransferase 1 (DNMT1). DNMT1 is a “gene silencer,” that is responsible for the maintenance of DNA methylation and contribution to de novo methylation. Implications of DNMT1′s involvement in the expression of UV-induced proteins have been previously reported.
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