Diastereoselective sulfur oxidation of 2-thio-3-chloroacrylamides

Add time:08/07/2019    Source:sciencedirect.com

Diastereoselective sulfur oxidation in 2-thio-3-chloroacrylamides is described. A range of chiral amine auxiliaries was incorporated in the β-chloroacrylamide, and the efficiency with which the stereochemistry was relayed to the sulfur centre during sulfoxidation was investigated. Diastereomeric ratios of up to 3.3:1 were achieved.

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