Cell Surface Effects of a PHTHALANILIDE (cas 16497-41-9) Derivative

Add time:08/07/2019    Source:sciencedirect.com

Using the technique of cell electrophoresis to estimate surface charge density of mammalian tumor cells, a PHTHALANILIDE (cas 16497-41-9) derivative (NSC 38280) caused a significant fall in cell electrophoretic mobility. These results suggest that the drug forms an irreversible complex with cell surface components, thereby lowering their zeta potential. The cell aggregation may account for the thromboembolism noted clinically.

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