α−Calcitonin gene-related peptide inhibits autophagy and calpain systems and maintains the stability of neuromuscular junction in denervated muscles

Add time:08/08/2019    Source:sciencedirect.com

Objectiveα-Calcitonin gene-related peptide (CGRP) is a neuropeptide widely distributed in the central and peripheral nervous systems involved in the stabilization of muscle-type cholinergic receptors nicotinic subunits (AChR). However, the underlying mechanism by which this neuropeptide regulates skeletal muscle protein metabolism and neuromuscular junction (NMJ) morphology is unclear.

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