Direct synthesis of Cbz-protected (2-amino)-6-(2-aminoethyl)pyridines

Add time:07/13/2019    Source:sciencedirect.com

A novel series of (2-amino)-6-(2-aminoethyl)pyridines were prepared by a convenient Suzuki–Miyaura coupling approach from 2-amino-6-bromopyridines. Benzyl vinylcarbamate was first treated with 9-BBN followed by aqueous NaOH and then the appropriate bromopyridine precursors were added into the mixture. The mixture was finally heated in presence of a palladium catalyst to provide the corresponding products in overall high yields. The procedure is extended to the preparation of related pyrazine and pyrimidine compounds as well as (2-amido)- and (2-alkoxy)-6-(2-aminoethyl)pyridines.

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