Regioselective opening of epoxyaldonolactones to fluorodeoxyaldonolactones using Tetrabutylammonium dihydrogentrifluoride

Add time:08/08/2019    Source:sciencedirect.com

A study on the hydrofluorination of epoxyaldonolactones with Bu4N+H2F3− (1) under solid-liquid PTC and homogeneous conditions has been performed. Unsubstituted 5,6-epoxy-hexono-1,4-lactones 2a give the corresponding fluorohydrins in high yield using catalytic amounts of 1 and an excess of solid KHF2, while an equimolar amount of 1 is used with 2,3-epoxyaldonolactones 2d–g and 5,6-epoxy-hexono-1,4-lactones containing a free hydroxy group 2b,c. In all cases the reaction is completely regio- and stereoselective affording 6-deoxy-6-fluoro-hexonolactones 3a,b and 2-deoxy-2-fluoro-aldonolactones 3d,f.

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