One-pot synthesis of annulated pyrido[2,3-d:6,5-d]dipyrimidine derivatives using nitrogen based DBU catalyst in aqueous ethanol medium

Add time:08/13/2019    Source:sciencedirect.com

We have reported DBU as an efficient organocatalyst for one-pot three-component synthesis of annulated pyrido[2,3-d:6,5-d]dipyrimidine derivatives using aromatic aldehyde, thio-barbituric acid and 6-amino-uracil in aqueous ethanol under reflux. The attractive advantages of this process are mild reaction conditions, environment friendly procedure, short reaction times, easy isolation of products, and excellent yields (72–89%).

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