A bis-hydrazone derivative of 2,5-furandicarboxaldehyde with perfect hetero-atomic cavity for selective sensing of Hg(II) and its intracellular detection in living HeLa S3 cell

Add time:08/11/2019    Source:sciencedirect.com

A new bis-hydrazone derivative of 2,5-furandicarboxaldehyde (R1) was designed with perfect hetero-atomic cavity and synthesized for sensing of heavy metal ion via FRET mechanism. Selective sensing ability of R1 as a ‘turn on’ fluorescent chemosensor for Hg2+ with rapid and very sharp visual colour change was observed. The long wavelength fluorescence emission of R1:Hg2+ complex was applied for intracellular Hg2+ detection in living HeLa S3 cells. Single crystal X-ray confirmed the structure and LOD calculation suggested that the sensor could identify very low concentration (3.6 nM) of Hg2+. Quantum chemical (DFT) calculation supported the symmetrical three dimensional structural arrangements as well as the chelate complex of the sensor with Hg2+.

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