2-Amino-2-oxazoline Formation by Cyclization of 1-(2-Hydroxyethyl)-2-methyl-2-thiopseudoureas

Add time:07/17/2019    Source:sciencedirect.com

1-(2-Hydroxyethyl)-3-substituted-2-methyl-2-thiopseu-dourea hydriodides, when heated in polar solvents, were found in many instances to result in the formation of 2-amino-2-oxazoline derivatives with the simultaneous evolution of methyl mercaptan. The rate of the reaction is apparently influenced by the group substituted in the 3-position of the thiopseudourea. Similarly, the 5,6-dihydro-4H-1,3-oxazine ring system could be prepared by starting with a 1-(3-hydroxypropyl)-2-thiourea.

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